Medicinal Products

ALGICALM 400 mg / 25 mg

Generic drug of the therapeutic class: Analgesics
active ingredients: Paracetamol, Codeine
laboratory: Grunenthal

Box of 16
All forms


Symptomatic treatment of pain of moderate to intense intensity or not responding to the use of peripheral analgesics used alone.

Dosage ALGICALM 400 mg / 25 mg Tablet Box of 16


1 tablet, to be renewed if necessary after 4 hours, or possibly 2 tablets in case of severe pain, without exceeding 6 tablets per day.

The maximum daily dosage is 3 g of paracetamol and 120 mg of codeine.

The catches must be spaced at least 4 hours apart.

In case of severe renal insufficiency (creatinine clearance less than 10 ml / min), the interval between two doses will be at least 8 hours.

Against indications

· In addition to a punctual dose, this medicine is contraindicated during breastfeeding (see section Pregnancy and breastfeeding ).

· Child under 15 years old.

· Related to paracetamol:

o allergy to paracetamol,

o hepatocellular insufficiency.

· Linked to codeine:

o respiratory insufficiency,

o allergy to codeine.

Relative contraindication:

· Association with morphine agonists-antagonists (buprenorphine, nalbuphine, pentazocine).

Algicalm side effects

Linked to codeine :

· At therapeutic doses the side effects of codeine are comparable to those of other opiates, but they are more rare and moderate.
Possibility of:

o constipation, nausea, vomiting

o drowsiness, dizzy states

o allergic skin reactions

o bronchospasm, respiratory depression (see section 4.3 )

· There is a risk of dependency and. withdrawal syndrome, which can be observed in the user and in the newborn of a mother poisoned with codeine.

Related to paracetamol :

· A few rare cases of allergic accidents are manifested by simple cutaneous rashes with erythema or urticaria and require the cessation of treatment.

· Very exceptional cases of thrombocytopenia have been reported.

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