Medicinal Products

AMOXICILLIN / AC CLAV ARROW Ad 1 g / 125 mg

Generic drug of Adult Augmentin
Therapeutic class: Infectiology - Parasitology
active ingredients: Amoxicillin, Clavulanic acid
laboratory: Arrow Generic

Powder for oral suspension
Box of 12 sachets-dose
All forms

Indication

- They proceed from the antibacterial activity and pharmacokinetic characteristics of this drug. They take into account both the clinical studies it has given and its place in the range of antibacterial products currently available.
- They are limited to infections due to sensitive organisms, especially in certain situations where the bacterial species responsible for the infection can be multiple and / or resistant to the antibiotics currently available.
- On this basis, this medicinal product is of particular interest in the following indications:
. acute otitis media of the adult,
. acute maxillary sinusitis and other forms of sinusitis,
. superinfections of acute bronchitis of the patient at risk, in particular chronic ethyl, smoking, aged over 65 years, in case of evolutionary risk or second intention,
. exacerbations of chronic bronchopneumopathies,
. acute pneumopathies of patients at risk, including chronic ethyl, smoking, over 65 years of age or with swallowing disorders,
. recurrent acute cystitis, uncomplicated cystitis in women and uncomplicated acute pyelonephritis due to susceptible organisms,
. high gynecological infections, in combination with another antibiotic active on Chlamydiae (see precautions for use),
. periodontitis,
. severe stomatologic infections: abscesses, phlegmons, cellulitis,
. relay treatment of the injectable route.
- Official recommendations regarding the proper use of antibacterials should be taken into account.

Dosage AMOXICILLIN / AC CLAV ARROW Ad 1g / 125mg Powder for oral suspension Box of 12 Sachets-dose

Dosages expressed as amoxicillin :
ADULTS (weight> = 40 kg) :
PATIENT WITH NORMAL RENAL FUNCTION:
- 2 g / day in 2 doses in the following indications:
. acute maxillary sinusitis,
. superinfections of acute bronchitis of the patient at risk, in particular chronic ethyl, smoking, aged over 65 years, in case of evolutionary risk or second intention,
. exacerbations of chronic bronchopneumopathies,
. periodontitis.
- 3 g / day in 3 takes in the following indications:
. other forms of sinusitis,
. acute otitis media,
. recurrent acute cystitis, uncomplicated cystitis in women and uncomplicated acute pyelonephritis due to susceptible organisms,
. high gynecological infections, in combination with another antibiotic active on Chlamydiae (see precautions for use),
. severe stomatologic infections: abscesses, phlegmons, cellulitis,
. acute pneumopathies of patients at risk, including chronic ethyl, smoking, over 65 years of age or with swallowing disorders,
. relay treatment of the injectable route.
IN PATIENT INSUFFICIENT RENAL:
Creatinine clearance: Dosage regimen .
. Greater than 30 ml / min : No dose adjustment necessary.
. Between 10 and 30 ml / min : 1 g / 125 mg every 12 to 24 hours.
. Less than 10 ml / min : For patients treated or not with hemodialysis, the conditions of use have not been established.
PATIENT AGE:
No dose adjustment unless creatinine clearance is <= 30 ml / min (see dosage in patients with renal impairment).
Mode of administration :
Oral way.
The contents of the sachet-dose is to be dispersed in half a glass of water before ingestion.
Take the medicine preferably at the beginning of the meal.

Against indications

CONTRAINDICATED:
This medicine MUST NEVER BE USED in case of:
- allergy to antibiotics of the beta-lactam family (penicillins, cephalosporins): take into account the risk of cross-reactivity with antibiotics of the cephalosporin group,
- allergy to one of the constituents,
- history of liver injury related to the amoxicillin / clavulanic acid combination,
- phenylketonuria, due to the presence of aspartame (E951).
Due to the presence of maltodextrin (glucose), this drug is contraindicated in case of glucose and galactose malabsorption syndrome.
NOT RECOMMENDED :
This medicine IS GENERALLY NOT RECOMMENDED when combined with methotrexate (see interactions).

Adverse effects Amoxicillin / AC Clav Arrow AD

- Gastrointestinal manifestations: nausea, vomiting, possibility of gastrointestinal overinfections with Candida, diarrhea, loose stools, dyspepsia and abdominal pain.
Some cases of pseudomembranous colitis and haemorrhagic colitis have been reported.
- Allergic manifestations: including urticaria, eosinophilia, angioedema, respiratory discomfort, serum sickness, vasculitis, exceptionally anaphylactic shock.
- Maculopapular rashes of allergic origin or not.
Very occasionally, some cases of Lyell's syndrome and Stevens-Johnson, erythema multiforme, and exfoliative dermatitis have been reported.
These skin manifestations may be more frequent and / or more intense in patients with infectious mononucleosis or evolving lymphoid leukemia.
Very rare cases of acute generalized exanthematous pustulosis (see warnings and precautions for use).
- Other events have been reported more rarely:
. cases of hepatitis, usually cholestatic or mixed, have occasionally been reported. These cases seem to be more likely to occur in elderly and male patients, and for more than 10 days of treatment and especially for treatments longer than 15 days. Symptoms, including jaundice that appears consistent, occur during or at the end of treatment, but may occur a few weeks after stopping. Histopathological examination of the liver usually reveals centrilobular cholestasis. The evolution is generally favorable but can be prolonged by a few weeks.
Some extremely rare cases of fatal evolution have been observed.
. moderate and asymptomatic increases in ASAT, ALT or alkaline phosphatase;
. acute interstitial nephritis;
. leukopenia, neutropenia, agranulocytosis, hemolytic anemia, reversible thrombocytopenia.
- Cases of convulsions have been exceptionally reported (see warnings and precautions for use).
Very rare cases of superficial dental stains, generally reversible after brushing, have been reported with forms for oral suspension.

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