Medicinal Products

ANCOTIL 1%

Generic drug of the therapeutic class: Infectiology - Parasitology
active ingredients: Flucytosine
laboratory: Meda Pharma

Injection solution for IV infusion
Box of 5 bottles of 250 ml
All forms

Indication

Severe systemic fungal infections, including candidiasis, cryptococcosis, chromomycosis and some forms of aspergillosis.

Association with another antifungal:

It is essential to use flucytosine in combination to avoid as much as possible the selection of resistant mutants, especially in the treatment of candidiasis and cryptococcosis.

The association with amphotericin B is often synergistic and never antagonistic.

Dosage ANCOTIL 1% Solution for injection for IV infusion Box of 5 bottles of 250 ml

INTRAVENOUS PATH FOR INFUSION.

The dosage varies from 100 to 200 mg / kg per day depending on the nature of the infection, its location and the sensitivity of the causative agent.

Continuous or discontinuous intravenous infusions should be divided among the 24 hours. The duration of the infusion will be on average 45 minutes.

The duration of treatment is also a function of the nature of the infection, its location and the sensitivity of the responsible agent.

USE IN RENAL INSUFFICIENT:

The doses will be administered at longer intervals according to the following dosage schedule:

CLEARANCE OF CREATININE

DOSE BY SOCKET

INTERVAL

≥ 40 ml / min

25 to 50 mg / kg

6 hours

20≤Cl <40 ml / min

25 to 50 mg / kg

12 hours

10 Cl Cl <20 ml / min

25 to 50 mg / kg

24 hours

Cl <10 ml / min

Single dose of 25 mg / kg then plasma control 12 hours after the initial dose, before repeating the dose.

DIALYSIS DISEASES

Since flucytosine is dialysable, the dose of this drug should be repeated after each treatment session.

ASSOCIATIONS WITH OTHER ANTIFUNGALS

The flucytosine-amphotericin B combination is synergistic: it sometimes makes it possible to reduce the dosage and to reduce the risk of occurrence of secondary resistance to flucytosine.

There does not seem to be any antagonism with the imidazole derivatives.

Against indications

This drug is contraindicated in case of hypersensitivity to any of the constituents.

The use of this medication is generally not recommended during pregnancy.

Ancotil side effects

· Digestive disorders such as nausea, diarrhea, more rarely vomiting.

· Blood disorders: (leukopenia, thrombocytopenia), most often moderate and transient and more frequent in cases of renal insufficiency or when serum levels of flucytosine are greater than 100 μg / ml. More severe lesions (aplasia, agranulocytosis), which may be irreversible and may exceptionally lead to death, have sometimes been observed, most often in patients who, moreover, undergo treatment with spinal toxicity.

· Hepatic disorders: Elevated transaminase levels (ASAT, ALT), alkaline phosphatase, regressive at discontinuation of treatment and rare acute hepatitis have sometimes been observed.

· Exceptional cardiac disorders usually of ischemic pace.

· Allergic manifestations: rare cases of skin rash and exceptional cases of Lyell's syndrome.

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