Gout is the most common inflammatory arthritis.
It is often seen in men over 40, but cases of female gout increase.
Before the onset of the first bout of joint gout, this disease can be asymptomatic. The urate crystals accumulate in the joints in a silent way, without giving any symptoms. Unpredictably, these crystals precipitate in the joint and cause acute gout, leading to local inflammation and pain.
The gouty access of the big toe is the most common and well-known clinical form.
A gout attack typically causes total functional impotence with very severe pain, preventing the patient from sleeping. The big toe is red, hot, swollen. It is inflammatory nocturnal pain. It lasts several days without treatment.
In the blood, there is hyperuricemia, that is to say an abnormal increase in the concentration of uric acid in the blood.
The succession of gout attacks in the different joints leads to uterine arthropathies: it is a chronic attack of the joints.
Deposition of urates in the joints causes mechanical pains different from those of gout attacks themselves; they appear to movements and are calmed by rest.
The urates are also deposited in the tissues that surround the joints they are tophi, they form yellowish knots rather characteristic around the joints of the fingers of the hands for example or big toes, feet, tendons of Achilles, elbows, at the level ears too ...
Renal involvement is more serious than that of the joints; it is the gravity of hyperuricemia. Urate crystals can form stones in the urinary tract, or they are deposited in the kidney tissue; kidney function gradually deteriorates, and this leads to kidney failure.
To avoid this irreversible evolution, hyperuricemia must be treated.