Medicinal Products

PEDIAVEN AP-HP CHILD G20 Solution for infusion Box of 4 Pockets of 1000 ml

Generic drug of the therapeutic class: Anesthesia, resuscitation, analgesics
Active Ingredients: Glucose, Alanine, Arginine, Aspartic Acid, Cysteine, Glutamic Acid (E620), Glycine, Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Proline, Serine, Taurine, Threonine, Tryptophan, Tyrosine, Valine, Gluconate calcium (E578), C
lab: HP Public Support

Injection solution for IV infusion
All forms

Indication

- Basic support for parenteral nutrition of the child in stable condition without nutritional imbalance when oral or enteral feeding is impossible, insufficient or contraindicated and for short periods (up to 2 weeks).
- Caloric intake of carbohydrate, nitrogen (amino acids of the L series). Contribution in electrolytes and trace elements.

Dosage PEDIAVEN AP-HP CHILD G20 Solution for infusion Box of 4 Pockets of 1000 ml

Dosage:
- The dosage is individual and varies according to age, weight, metabolic and energy needs, as well as the clinical condition of the patient.
- As an indication, in children, an average of 10 to 15 grams / kg / day of glucose is required at an hourly flow rate of 1 to 1.2 g / kg / hour and 200 to 300 mg / kg / day of nitrogen.
- PEDIAVEN AP-HP CHILD G20 must be administered at a maximum hourly rate of 6 ml / kg / h.
Supplementation:
- This nutrient solution can be supplemented, on the express condition of having first verified the validity of the combination and the stability of the final mixture.
- In case of supplementation, the additions must be carried out under strict aseptic conditions, with specialties whose compatibility has been tested.
It is preferable that the addition of a lipid emulsion is not carried out directly in the bag or in the tubing because of the risk of destabilization of the lipid emulsion by the divalent cations contained in the solution.
- Addition of vitamins :
. In case of exclusive parenteral nutrition, vitamin supplementation is recommended.
. Stability was shown for a mixture comprising 1000 ml of PEDIAVEN AP-HP CHILD G20 and 7.5 ml of the vitamin solution having the following composition per 5 ml of solution (note: the mixture obtained is yellow):
. For 5 ml :
Thiamine (B1): 3.51 mg.
Riboflavin (B2): 4.14 mg.
Nicotinamide (PP, B3): 46 mg.
Ac. Pantothenic (B5): 17.25 mg.
Pyridoxine (B6): 4.53 mg.
Biotin (B8): 0.069 mg.
Folic acid (B9): 0.414 mg.
Cyanocobalamin (B12): 0.006 mg.
Ac. ascorbic acid (C) 125 mg.
Vitamin A (retinol): 3500 IU.
Vitamin E (tocopherol): 10.2 IU.
Vitamin D3: 220 IU.
. After adding vitamins, protect the pocket of light.
Administration mode :
- Central intravenous infusion exclusively.
- Given its high osmolarity (1549 mOsm / L), the solution PEDIAVEN AP-HP CHILD G20 should not be infused into a peripheral vein, because of the risk of thrombophlebitis at the infusion site.

Against indications

- Known hypersensitivity to a component of the solution.
- Renal glomerular insufficiency.
- Need for restriction of sodium intake.
- Congenital abnormality of amino acid metabolism.

Adverse effects Pediaven AP-HP Child G20

- Potential adverse effects may occur:
. hyperglycemia if the hourly flow rate of glucose infused exceeds the patient's glucose utilization capacity (variable depending on age and disease status);
. transient disruption of liver function parameters;
. hypersensitivity reactions to certain amino acids;
. thrombophlebitis may occur when perfusion is performed intravenously peripheral.
- In case of excessive intake of amino acids, metabolic acidosis and hyperazotemia may occur especially in cases of renal or respiratory failure.
- The appearance of any uncontrolled abnormal signs (including chills, sweating, fever, difficulty breathing) must stop the infusion. Sepsis related to the catheter should be sought.

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