Medicinal Products


Generic drug of the therapeutic class: Anesthesia, resuscitation, analgesics
active ingredients: Thiopental sodium
laboratory: Hospira Enterprises BV

Powder for solution for injection
Box of 25 vials of 500 mg
All forms


Induction and maintenance of intravenous general anesthesia (alone or in combination).

Dosage PENTOTHAL 500 mg Powder for solution for injection Box of 25 vials of 500 mg

- This product should be administered only by physicians specialized in anesthesia-resuscitation or emergency medicine and familiar with the use of anesthetics, or under their control, and having all necessary anesthesia-resuscitation equipment.
- The recommendations of the scholarly societies concerned must be respected, especially when used in an out-of-hospital situation (emergency situation or medical transport).
Administration mode :
Intravenous way.
The dosage of thiopental is individual. It is therefore necessary to find, by practicing the injection, the minimum anesthetic dose for each patient, which requires a very slow injection rate. In certain resistant subjects, it is not necessary to insist on obtaining anesthesia in high doses, but to continue it with a volatile or gaseous anesthetic.
For information,
- In adults:
. induction : 3 to 5 mg / kg with possibility of successive injections of 50 to 100 mg every 30 seconds until anesthesia is obtained.
Average total dose of 0.3 to 1 g.
. maintenance : reinjection of decreasing doses on demand. The total dose may range from 0.75 to 1 g for anesthesia of 40 to 60 minutes. As a general rule, the 1g dose should not be exceeded to avoid delayed awakenings.
- In children:
. induction : Thiopental solution, diluted to 2.5% in water for injection, is injected slowly at 30 second intervals for a dose of 4 to 5 mg / kg.
Average total dose of 0.1 to 0.5 g.
. maintenance : reinjection, on demand, of decreasing doses of thiopental diluted to 2.5%. For example, the maintenance dose for a child of 30 to 50 kg is 25 to 50 mg injected on demand.
- In the elderly subject:
It is advisable to reduce the dosage.

Against indications

This medicine is contraindicated in the following cases:
- hypersensitivity to barbiturates,
- respiratory obstruction,
- severe acute asthma, asthmatic status,
- porphyria.
This medicine is generally not recommended in the following cases:
- cardiovascular failure,
- hypotension, shock,
- Addison's disease,
- renal or hepatic insufficiency,
- severe anemia,
- myasthenia,
- myxedema,
- asthma.
Breast-feeding: As the passage through the breast milk is not known, suspend breastfeeding for 24 hours after anesthesia.
Association advised against : alcohol.

Pentothal side effects

- hypersensitivity including anaphylactic shock,
- involuntary muscle movements,
coughing, sneezing, broncho-laryngospasm particularly during the induction period,
- low blood pressure,
- Cardiac arrythmia,
- respiratory depression,
- nausea, postoperative vomiting,
- dizziness, confusion, amnesia, headache,
- Moderate and transient functional liver disturbances. Exceptionally hepatitis.

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