Medicinal Products


Generic drug of Torental LP
Therapeutic class: Cardiology and angiology
active ingredients: Pentoxifylline
laboratory: Sandoz

Extended release film-coated tablet
Box of 30
All forms


- Symptomatic treatment of intermittent claudication of chronic occlusive arterial diseases of the lower limbs (stage 2).
NB: this indication is based on double-blind clinical trials compared to placebo which show an increase of the perimeter of walking of at least 50% in 50 to 60% of treated patients against 20 to 40% of patients following only rules diet and lifestyle.
- Adjunctive treatment for the symptomatic aim of chronic cognitive and neurosensory pathological deficit in the elderly (excluding Alzheimer's disease and other dementias).

Dosage PENTOXIFYLLINE LP GNR 400 mg Extended Release Film Tablet Box of 30

- 1 to 3 tablets per day, possibly in 2 unequal doses, preferably during the meal or meals.
- In patients with renal insufficiency, do not exceed 2 tablets per day. In case of severe renal insufficiency, the dose should be reduced and adapted according to individual tolerance.
Due to the prolonged release process, the tablet membrane can exceptionally be found in the stool.
Administration mode :
Oral way.
Swallow the tablet without chewing it with a little water.

Against indications

This medicine should never be used in the following cases:
hypersensitivity to pentoxifylline or to any of the excipients of the tablet.
- acute phase of myocardial infarction.
- ongoing hemorrhage or major bleeding risk.
This medicine is mainly used in elderly people for whom the risk of pregnancy is absent. In the absence of relevant clinical data, the use of the active substance is not recommended during pregnancy. Due to passage into breast milk, the use of pentoxifylline should be avoided during breastfeeding.

Side effects Pentoxifylline LP Gnr

- Digestive side effects such as: transient nausea, vomiting, gastric burns or diarrhea can be observed.
- Rarely hot flushes, arterial hypotension, headache, dizziness, insomnia, agitation may occur.
- Skin reactions (rash, urticaria, pruritus) are exceptionally observed, and isolated cases of anaphylactoid reactions with shock, angioedema and bronchospasm have been reported. At the first sign of such hypersensitivity reactions, treatment should be discontinued and appropriate therapeutic measures taken.
- A few cases of haemorrhage and / or decreased prothrombin levels have been reported in patients treated with pentoxifylline and with haemorrhagic risk factors (recent surgery, peptic ulcer) or receiving anticoagulants or antiplatelet agents.
- Thrombocytopenia, cholestasis or increased aminotransferase activity have been reported.

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